Also known as Palazzo Samuelli, from the name of the family who still lived there in the eighteenth century, the building had belonged to the important Affaitati family, who already owned an altar in the nearby church of Santa Maria di Nazareth in the sixteenth century, where a burial is also recorded linked to their name.
The palace was built in the 16th century and has three floors. Of particular interest is the façade, characterized by an external curtain worked in ashlar. It has a rustic style on the ground floor, with freshly rough-hewn ashlars, while in the upper part of the lateral bays, the ashlar takes on the shape of a diamond.
In the middle of the facade, on the upper floors, the façade is smooth due to a nineteenth-century intervention.
In the center there is an elegant portal framed by Corinthian pilasters and a richly decorated entablature, with the motif of winged Victory in the plumes.
Beyond the door, the monumental atrium ends in a courtyard featuring an 18th-century open staircase.